Personalized combination nano-immunotherapy for robust induction and tumor infiltration of CD8⁺ T cells.

ABSTRACT: Identification of tumor-specific mutations, called neoantigens, offers new exciting opportunities for personalized cancer immunotherapy. However, it remains challenging to achieve robust induction of neoantigen-specific T cells and drive their infiltration into the tumor microenvironment (TME). Here, we have developed a novel polyethyleneimine (PEI)-based personalized vaccine platform carrying neoantigen peptides and CpG adjuvants in a compact nanoparticle (NP) for their spatio-temporally concerted delivery. The NP vaccine significantly enhanced activation and antigen cross-presentation of dendritic cells, resulting in strong priming of neoantigen-specific CD8⁺ T cells with the frequency in the systemic circulation reaching as high as 23 ± 7% after a single subcutaneous administ

SUBMITTER: Park KS 

PROVIDER: S-EPMC8184601 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature