Liver Fibrosis is Associated with Ischemic Stroke Risk in Women but not Men: The REGARDS Study.

ABSTRACT:

Background

Nonalcoholic fatty liver disease is inconsistently associated with ischemic stroke, with one study suggesting an association in women and not men. The relative importance of liver fibrosis, as opposed to fatty liver, for cardiovascular risk is increasingly appreciated. We hypothesized that advanced liver fibrosis is associated with incident ischemic stroke risk, and especially in women.

Methods

We performed a case-cohort study in the REasons for Geographic and Racial Differences in Stroke cohort. Black and white individuals aged 45 and older were recruited between 2003 and 2007 and followed for ischemic stroke. The Fibrosis-4 (FIB-4) score and Nonalcoholic Fatty Liver Disease Fibrosis Score (NFS) were calculated using baseline data for stroke cases and a cohort ra

SUBMITTER: Parikh NS 

PROVIDER: S-EPMC8184639 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature