Metabolic control of daily locomotor activity mediated by tachykinin in Drosophila.

ABSTRACT: Metabolism influences locomotor behaviors, but the understanding of neural curcuit control for that is limited. Under standard light-dark cycles, Drosophila exhibits bimodal morning (M) and evening (E) locomotor activities that are controlled by clock neurons. Here, we showed that a high-nutrient diet progressively extended M activity but not E activity. Drosophila tachykinin (DTk) and Tachykinin-like receptor at 86C (TkR86C)-mediated signaling was required for the extension of M activity. DTk neurons were anatomically and functionally connected to the posterior dorsal neuron 1s (DN1_ps) in the clock neuronal network. The activation of DTk neurons reduced intracellular Ca²⁺ levels in DN1_ps suggesting an inhibitory connection. The contacts between DN1_p</

SUBMITTER: Lee SH 

PROVIDER: S-EPMC8184744 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature