Anatomical dissociation of intracerebral signals for reward and punishment prediction errors in humans.

ABSTRACT: Whether maximizing rewards and minimizing punishments rely on distinct brain systems remains debated, given inconsistent results coming from human neuroimaging and animal electrophysiology studies. Bridging the gap across techniques, we recorded intracerebral activity from twenty participants while they performed an instrumental learning task. We found that both reward and punishment prediction errors (PE), estimated from computational modeling of choice behavior, correlate positively with broadband gamma activity (BGA) in several brain regions. In all cases, BGA scaled positively with the outcome (reward or punishment versus nothing) and negatively with the expectation (predictability of reward or punishment). However, reward PE were better signaled in some regions (such as the ventromedi

SUBMITTER: Gueguen MCM 

PROVIDER: S-EPMC8184756 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature