Aging mitigates the severity of obesity-associated metabolic sequelae in a gender independent manner.

ABSTRACT:

Background

Understanding gender-associated bias in aging and obesity-driven metabolic derangements has been hindered by the inability to model severe obesity in female mice.

Methods

Here, using chow- or high fat diet (HFD)-feeding regimens at standard (T_S) and thermoneutral (T_N) housing temperatures, the latter to model obesity in female mice, we examined the impact of gender and aging on obesity-associated metabolic derangements and immune responsiveness. Analysis included quantification of: (i) weight gain and adiposity; (ii) the development and severity of glucose dysmetabolism and non-alcoholic fatty liver disease (NAFLD); and (iii) induction of inflammatory pathways related to metabolic dysfunction.

Results

We show that under chow diet feedi

SUBMITTER: Moreno-Fernandez ME 

PROVIDER: S-EPMC8184786 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature