RRBP1 rewires cisplatin resistance in oral squamous cell carcinoma by regulating Hippo pathway.

ABSTRACT:

Background

Chemoresistance is one of the major factors for treatment failure in OSCC. Identifying key resistance triggering molecules will be useful strategy for developing novel treatment methods.

Methods

To identify the causative factors of chemoresistance, we performed RNA sequencing and global proteomic profiling of human OSCC lines presenting with sensitive, early and late cisplatin-resistance patterns.

Results

From the common set of dysregulated genes from both the analysis, RRBP1 was identified to be upregulated in both early and late cisplatin-resistant cells with respect to the sensitive counterpart. Analysis of OSCC patient sample indicates that RRBP1 expression is upregulated in chemotherapy-non-responder tumours as compared to chemotherapy-responder tumour

SUBMITTER: Shriwas O 

PROVIDER: S-EPMC8184829 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature