Reversed and increased functional connectivity in non-REM sleep suggests an altered rather than reduced state of consciousness relative to wake.

ABSTRACT: Sleep resting state network (RSN) functional connectivity (FC) is poorly understood, particularly for rapid eye movement (REM), and in non-sleep deprived subjects. REM and non-REM (NREM) sleep involve competing drives; towards hypersynchronous cortical oscillations in NREM; and towards wake-like desynchronized oscillations in REM. This study employed simultaneous electroencephalography-functional magnetic resonance imaging (EEG-fMRI) to explore whether sleep RSN FC reflects these opposing drives. As hypothesized, this was confirmed for the majority of functional connections modulated by sleep. Further, changes were directional: e.g., positive wake correlations trended towards negative correlations in NREM and back towards positive correlations in REM. Moreover, the majority did not merely

SUBMITTER: Houldin E 

PROVIDER: S-EPMC8184935 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature