Urine NMR-based TB metabolic fingerprinting for the diagnosis of TB in children.

ABSTRACT: Tuberculosis (TB) is a major cause of morbidity and mortality in children, and early diagnosis and treatment are crucial to reduce long-term morbidity and mortality. In this study, we explore whether urine nuclear magnetic resonance (NMR)-based metabolomics could be used to identify differences in the metabolic response of children with different diagnostic certainty of TB. We included 62 children with signs and symptoms of TB and 55 apparently healthy children. Six of the children with presumptive TB had bacteriologically confirmed TB, 52 children with unconfirmed TB, and 4 children with unlikely TB. Urine metabolic fingerprints were identified using high- and low-field proton NMR platforms and assessed with pattern recognition techniques such as principal components analysis and partial

SUBMITTER: Comella-Del-Barrio P 

PROVIDER: S-EPMC8184981 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature