H3K36 methyltransferase NSD1 regulates chondrocyte differentiation for skeletal development and fracture repair.

ABSTRACT: Chondrocyte differentiation is a critical process for endochondral ossification, which is responsible for long bone development and fracture repair. Considerable progress has been made in understanding the transcriptional control of chondrocyte differentiation; however, epigenetic regulation of chondrocyte differentiation remains to be further studied. NSD1 is a H3K36 (histone H3 at lysine 36) methyltransferase. Here, we showed that mice with Nsd1 deficiency in Prx1⁺ mesenchymal progenitors but not in Col2⁺ chondrocytes showed impaired skeletal growth and fracture healing accompanied by decreased chondrogenic differentiation. Via combined RNA sequencing (RNA-seq) and chromatin immunoprecipitation sequencing (ChIP-seq) analysis, we identified sex determining region Y b

SUBMITTER: Shao R 

PROVIDER: S-EPMC8185073 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature