TET1-mediated DNA hydroxymethylation regulates adult remyelination in mice.

ABSTRACT: The mechanisms regulating myelin repair in the adult central nervous system (CNS) are unclear. Here, we identify DNA hydroxymethylation, catalyzed by the Ten-Eleven-Translocation (TET) enzyme TET1, as necessary for myelin repair in young adults and defective in old mice. Constitutive and inducible oligodendrocyte lineage-specific ablation of Tet1 (but not of Tet2), recapitulate this age-related decline in repair of demyelinated lesions. DNA hydroxymethylation and transcriptomic analyses identify TET1-target in adult oligodendrocytes, as genes regulating neuro-glial communication, including the solute carrier (Slc) gene family. Among them, we show that the expression levels of the Na⁺/K⁺/Cl^- transporter, SLC12A2, are higher in Tet1 overexpressing cells and l

SUBMITTER: Moyon S 

PROVIDER: S-EPMC8185117 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature