Interactive Effects of Glucocorticoids and Cytochrome P450 Polymorphisms on the Plasma Trough Concentrations of Voriconazole.

ABSTRACT: Aims: To explore the interactive influence of glucocorticoids and cytochrome P450 (CYP450) polymorphisms on voriconazole (VRC) plasma trough concentrations (C_min) and provide a reliable basis for reasonable application of VRC. Methods: A total of 918 VRC C_min from 231 patients was collected and quantified using high-performance liquid chromatography in this study. The genotypes of CYP2C19, CYP3A4, and CYP3A5 were detected by DNA sequencing assay. The effects of different genotypes and the coadministration of glucocorticoids on VRC C_min were investigated. Furthermore, the interactive effects of glucocorticoids with CYP450s on VRC C_min were also analyzed. Results: The median C_min of oral administ

SUBMITTER: Jia SJ 

PROVIDER: S-EPMC8185288 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature