Ontology highlight
ABSTRACT:
SUBMITTER: Pan B
PROVIDER: S-EPMC8185324 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Chembiochem : a European journal of chemical biology 20210129 8
Post-translational modifications (PTMs) can affect the normal function and pathology of α-synuclein (αS), an amyloid-fibril-forming protein linked to Parkinson's disease. Phosphorylation of αS Tyr39 has recently been found to display a dose-dependent effect on fibril formation kinetics and to alter the morphology of the fibrils. Existing methods to access site-specifically phosphorylated αS for biochemical studies include total or semi-synthesis by native chemical ligation (NCL) as well as chemo ...[more]