Native Cell Membrane Nanoparticles System for Membrane Protein-Protein Interaction Analysis.

ABSTRACT: Protein-protein interactions in cell membrane systems play crucial roles in a wide range of biological processes- from cell-to-cell interactions to signal transduction; from sensing environmental signals to biological response; from metabolic regulation to developmental control. Accurate structural information of protein-protein interactions is crucial for understanding the molecular mechanisms of membrane protein complexes and for the design of highly specific molecules to modulate these proteins. Many in vivo and in vitro approaches have been developed for the detection and analysis of protein-protein interactions. Among them the structural biology approach is unique in that it can provide direct structural information of protein-protein interactions at the atomic level. However, current

SUBMITTER: Kroeck KG 

PROVIDER: S-EPMC8185428 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature