Safety and Efficacy of Perioperative Intravenous Meloxicam for Moderate-to-Severe Pain Management in Total Knee Arthroplasty: A Randomized Clinical Trial.

ABSTRACT:

Objective

To evaluate the effect of perioperative meloxicam IV 30 mg on opioid consumption in primary total knee arthroplasty (TKA).

Design

Multicenter, randomized, double-blind, placebo-controlled trial.

Subjects

In total, 181 adults undergoing elective primary TKA.

Methods

Subjects received meloxicam 30 mg or placebo via an IV bolus every 24 hours, the first dose administered prior to surgery as part of a multimodal pain management protocol. The primary efficacy parameter was total opioid use from end of surgery through 24 hours.

Results

Meloxicam IV was associated with less opioid use versus placebo during the 24 hours after surgery (18.9 ± 1.32 vs 27.7 ± 1.37 mg IV morphine equivalent dose; P < 0.001) and was superior to placebo on secondary endpoint

SUBMITTER: Berkowitz RD 

PROVIDER: S-EPMC8185557 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature