Dataset Information

Pazopanib together with 6-8 cycles of sintilimab followed by single use of pazopanib in the second-line treatment of advanced renal cell carcinoma.

ABSTRACT:

Background

The aim of the study was to investigate the temporary combination of anti-PD-1 plus targeted therapy followed by single targeted therapy in advanced renal cell carcinoma (RCC) as second-line therapy.

Methods

A total of 17 patients from Fudan University Shanghai Cancer Center (FUSCC) with advanced clear cell RCC were enrolled. They were treated with sunitinib (50 mg/day; 2 weeks on and 1 weeks off) as first-line therapy. After progression of the disease, sintilimab (200 mg iv/q3w) in combination with pazopanib (800 mg/day) were used. After 6-8 cycles of immunotherapy, patients were treated with pazopanib only. Cox proportional hazards models was used to evaluate the risk factors.

Results

Three patients reached partial response (PR) after second-line treatment, while 12 patients remained stable. Two patients had progressive disease and 1 of them died due to disease progression. The median progression-free survival (PFS) for second-line therapy was 12.2 months. Cox analysis revealed that IMDC score (HR: 0.041, P=0.01) was the only factor that was correlated with progression free survival.

Conclusions

Tyrosine kinase inhibitors (TKIs), together with 6-8 cycles of immune checkpoint inhibitor (ICI) agents followed by the single use of a TKI, are a feasible way to treat metastatic clear cell RCC (ccRCC) patients as second-line treatment.

SUBMITTER: Lu X

PROVIDER: S-EPMC8185682 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature

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Publications

Pazopanib together with 6-8 cycles of sintilimab followed by single use of pazopanib in the second-line treatment of advanced renal cell carcinoma.

Lu Xiaolin X Gu Weijie W Shi Guohai G Ye Dingwei D

Translational andrology and urology 20210501 5

<h4>Background</h4>The aim of the study was to investigate the temporary combination of anti-PD-1 plus targeted therapy followed by single targeted therapy in advanced renal cell carcinoma (RCC) as second-line therapy.<h4>Methods</h4>A total of 17 patients from Fudan University Shanghai Cancer Center (FUSCC) with advanced clear cell RCC were enrolled. They were treated with sunitinib (50 mg/day; 2 weeks on and 1 weeks off) as first-line therapy. After progression of the disease, sintilimab (200 ...[more]

PMID: 34159088

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Project description:BackgroundPatients with advanced urothelial carcinoma that progresses after platinum-based chemotherapy have a poor prognosis and limited treatment options.MethodsIn this open-label, international, phase 3 trial, we randomly assigned 542 patients with advanced urothelial cancer that recurred or progressed after platinum-based chemotherapy to receive pembrolizumab (a highly selective, humanized monoclonal IgG4κ isotype antibody against programmed death 1 [PD-1]) at a dose of 200 mg every 3 weeks or the investigator's choice of chemotherapy with paclitaxel, docetaxel, or vinflunine. The coprimary end points were overall survival and progression-free survival, which were assessed among all patients and among patients who had a tumor PD-1 ligand (PD-L1) combined positive score (the percentage of PD-L1-expressing tumor and infiltrating immune cells relative to the total number of tumor cells) of 10% or more.ResultsThe median overall survival in the total population was 10.3 months (95% confidence interval [CI], 8.0 to 11.8) in the pembrolizumab group, as compared with 7.4 months (95% CI, 6.1 to 8.3) in the chemotherapy group (hazard ratio for death, 0.73; 95% CI, 0.59 to 0.91; P=0.002). The median overall survival among patients who had a tumor PD-L1 combined positive score of 10% or more was 8.0 months (95% CI, 5.0 to 12.3) in the pembrolizumab group, as compared with 5.2 months (95% CI, 4.0 to 7.4) in the chemotherapy group (hazard ratio, 0.57; 95% CI, 0.37 to 0.88; P=0.005). There was no significant between-group difference in the duration of progression-free survival in the total population (hazard ratio for death or disease progression, 0.98; 95% CI, 0.81 to 1.19; P=0.42) or among patients who had a tumor PD-L1 combined positive score of 10% or more (hazard ratio, 0.89; 95% CI, 0.61 to 1.28; P=0.24). Fewer treatment-related adverse events of any grade were reported in the pembrolizumab group than in the chemotherapy group (60.9% vs. 90.2%); there were also fewer events of grade 3, 4, or 5 severity reported in the pembrolizumab group than in the chemotherapy group (15.0% vs. 49.4%).ConclusionsPembrolizumab was associated with significantly longer overall survival (by approximately 3 months) and with a lower rate of treatment-related adverse events than chemotherapy as second-line therapy for platinum-refractory advanced urothelial carcinoma. (Funded by Merck; KEYNOTE-045 ClinicalTrials.gov number, NCT02256436 .).

Dataset Information

Pazopanib together with 6-8 cycles of sintilimab followed by single use of pazopanib in the second-line treatment of advanced renal cell carcinoma.

Background

Methods

Results

Conclusions

Publications

Pazopanib together with 6-8 cycles of sintilimab followed by single use of pazopanib in the second-line treatment of advanced renal cell carcinoma.

Similar Datasets

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