Characterization of terminal-ileal and colonic Crohn's disease in treatment-naive paediatric patients based on transcriptomic profile using logistic regression.

ABSTRACT:

Background

Inflammatory bowel disease (IBD) is a chronic and idiopathic inflammatory disorder of the gastrointestinal tract and comprises ulcerative colitis (UC) and Crohn's disease (CD). Crohn's disease can affect any part of the gastrointestinal tract, but mainly the terminal ileum and colon. In the present study, we aimed to characterize terminal-ileal CD (ICD) and colonic CD (CCD) at the molecular level, which might enable a more optimized approach for the clinical care and scientific research of CD.

Methods

We analyzed differentially expressed genes in samples from 23 treatment-naïve paediatric patients with CD and 25 non-IBD controls, and compared the data with previously published RNA-Seq data using multi-statistical tests and confidence intervals. We implemented func

SUBMITTER: Park I 

PROVIDER: S-EPMC8185924 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature