Correlating genomic copy number alterations with clinicopathologic findings in 75 cases of hepatocellular carcinoma.

ABSTRACT:

Background

Oligonucleotide array comparative genomic hybridization (aCGH) analysis has been used for detecting somatic copy number alterations (CNAs) in various types of tumors. This study aimed to assess the clinical utility of aCGH for cases of hepatocellular carcinoma (HCC) and to evaluate the correlation between CNAs and clinicopathologic findings.

Methods

aCGH was performed on 75 HCC cases with paired DNA samples from tumor and adjacent nontumor tissues. Survival outcomes from these cases were analyzed based on Barcelona-Clinic Liver Cancer Stage (BCLC), Edmondson-Steiner grade (E-S), and recurrence status. Correlation of CNAs with clinicopathologic findings was analyzed by Wilcoxon rank test and clustering vs. K means.

Results

The survival outcomes indicated tha

SUBMITTER: Peng G 

PROVIDER: S-EPMC8185937 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature