Recurrent KRAS, KIT and SF3B1 mutations in melanoma of the female genital tract.

ABSTRACT:

Background

Malignant melanoma of the female genital tract is relatively uncommon and accounts for 3-7% of all melanoma localizations. This study aimed to identify driver genes in melanoma of the female genital tract with the purpose of enhancing understanding of disease pathogenesis and identifying potential new therapeutic targets to develop effective therapies.

Methods

KIT (CD117) and BRAF expression were detected immunohistochemically. Polymerase Chain Reaction (PCR) and Sanger sequencing techniques were performed to identify the mutational status of BRAF, NRAS, KRAS, NF1, KIT, PDGFRA and SF3B1 on 19 melanomas of the female genital tract, paired with 25 cutaneous melanomas, 18 acral melanomas and 11 melanomas of nasal cavity.

Results

Somatic variant analysis identi

SUBMITTER: Cai YJ 

PROVIDER: S-EPMC8185938 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature