The global and promoter-centric 3D genome organization temporally resolved during a circadian cycle.

ABSTRACT:

Background

Circadian gene expression is essential for organisms to adjust their physiology and anticipate daily changes in the environment. The molecular mechanisms controlling circadian gene transcription are still under investigation. In particular, how chromatin conformation at different genomic scales and regulatory elements impact rhythmic gene expression has been poorly characterized.

Results

Here we measure changes in the spatial chromatin conformation in mouse liver using genome-wide and promoter-capture Hi-C alongside daily oscillations in gene transcription. We find topologically associating domains harboring circadian genes that switch assignments between the transcriptionally active and inactive compartment at different hours of the day, while their boundaries st

SUBMITTER: Furlan-Magaril M 

PROVIDER: S-EPMC8185950 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature