Initiating buprenorphine to treat opioid use disorder without prerequisite withdrawal: a systematic review.

ABSTRACT:

Background

Opioid withdrawal symptoms prior to buprenorphine initiation may be intolerable and as a result, alternative strategies have emerged. We aim to systematically review the efficacy and safety of buprenorphine initiation that aims to omit prerequisite withdrawal.

Methods

We conducted a systematic literature search of MEDLINE and CENTRAL from 1996 through April 10, 2020, augmented with searches in Google Scholar and www.clinicaltrials.gov . A study was included if it was in patients with substance use disorder or chronic pain that were taking a full mu opioid agonist and transitioning to buprenorphine without preceding withdrawal, and reported withdrawal during initiation as an outcome. Two investigators independently screened citations and articles for inclusion, col

SUBMITTER: Adams KK 

PROVIDER: S-EPMC8186092 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature