KI-67 LI Expression in Triple-Negative Breast Cancer Patients and Its Significance.

ABSTRACT:

Purpose

Triple-negative breast cancer (TNBC) is a subset of breast cancer which is known to carry a poor prognosis because of lack of targets for hormonal therapy. Research efforts have focused in recent years on discovering biomarkers of management in TNBCs. KI-67 Labelling Index (LI) is a nuclear protein which has proven to play diagnostic and prognostic roles in many cancers.

Materials and methods

We analysed the expression of KI-67 LI by immunohistochemistry in TNBC cases from the University hospital. This expression was cross-checked against clinical-pathological criteria of TNBC patients and against Vimentin expression in TNBC patients with significant KI-67 expression.

Results

KI-67 LI was significantly expressed in the majority of TNBC cases. This expression w

SUBMITTER: Arafah MA 

PROVIDER: S-EPMC8186110 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature