GNG5 is a novel oncogene associated with cell migration, proliferation, and poor prognosis in glioma.

ABSTRACT:

Background

Although many biomarkers have been reported for detecting glioma, the prognosis for the disease remains poor, and therefore, new biomarkers need to be identified. GNG5, which is part of the G-protein family, has been associated with different malignant tumors, though the role of GNG5 in glioma has not been studied. Therefore, we aimed to identify the relationship between GNG5 and glioma prognosis and identify a new biomarker for the diagnosis and treatment of gliomas.

Methods

We used data on more than a thousand gliomas from multiple databases and clinical data to determine the expression of GNG5 in glioma. Based on clinical data and CGGA database, we identified the correlation between GNG5 and multiple molecular and clinical features and prognosis using various a

SUBMITTER: Zhang W 

PROVIDER: S-EPMC8186147 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature