Phase Ib Study of Enzalutamide with or Without Sorafenib in Patients with Advanced Hepatocellular Carcinoma.

ABSTRACT:

Lessons learned

Androgen receptor as assessed by immunohistochemistry is expressed in a high proportion of patients with hepatocellular carcinoma (HCC). Enzalutamide at 160 mg orally daily is safe and tolerable in patients with advanced HCC but has no single-agent antitumor activity. Enzalutamide, a CYP3A4 inducer, at a standard dose of 160 mg reduces the exposure of sorafenib, a CYP3A4 substrate. Enzalutamide and sorafenib is safe and tolerable in patients with advanced HCC, but the addition of enzalutamide to sorafenib did not enhance the antitumor activity of sorafenib.

Background

Androgen receptor (AR) interference is deleterious to hepatocellular carcinoma (HCC) in preclinical models.

Methods

This is a multicenter, phase Ib study of enzalutamide ± sorafenib in pa

SUBMITTER: Harding JJ 

PROVIDER: S-EPMC8186405 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature