MGDrivE 2: A simulation framework for gene drive systems incorporating seasonality and epidemiological dynamics.

ABSTRACT: Interest in gene drive technology has continued to grow as promising new drive systems have been developed in the lab and discussions are moving towards implementing field trials. The prospect of field trials requires models that incorporate a significant degree of ecological detail, including parameters that change over time in response to environmental data such as temperature and rainfall, leading to seasonal patterns in mosquito population density. Epidemiological outcomes are also of growing importance, as: i) the suitability of a gene drive construct for release will depend on its expected impact on disease transmission, and ii) initial field trials are expected to have a measured entomological outcome and a modeled epidemiological outcome. We present MGDrivE 2 (Mosquito Gene Drive E

SUBMITTER: Wu SL 

PROVIDER: S-EPMC8186770 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature