Potential G-quadruplexes and i-Motifs in the SARS-CoV-2.

ABSTRACT: Quadruplex structures have been identified in a plethora of organisms where they play important functions in the regulation of molecular processes, and hence have been proposed as therapeutic targets for many diseases. In this paper we report the extensive bioinformatic analysis of the SARS-CoV-2 genome and related viruses using an upgraded version of the open-source algorithm G4-iM Grinder. This version improves the functionality of the software, including an easy way to determine the potential biological features affected by the candidates found. The quadruplex definitions of the algorithm were optimized for SARS-CoV-2. Using a lax quadruplex definition ruleset, which accepts amongst other parameters two residue G- and C-tracks, 512 potential quadruplex candidates were discovered. These

SUBMITTER: Belmonte-Reche E 

PROVIDER: S-EPMC8186786 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature