Association between obesity and risk of fracture, bone mineral density and bone quality in adults: A systematic review and meta-analysis.

ABSTRACT:

Background

The association between obesity and fracture risk may be skeletal site- and sex-specific but results among studies are inconsistent. Whilst several studies reported higher bone mineral density (BMD) in patients with obesity, altered bone quality could be a major determinant of bone fragility in this population.

Objectives

This systematic review and meta-analysis aimed to compare, in men, premenopausal women and postmenopausal women with obesity vs. individuals without obesity: 1) the incidence of fractures overall and by site; 2) BMD; and 3) bone quality parameters (circulating bone turnover markers and bone microarchitecture and strength by advanced imaging techniques).

Data sources

PubMed (MEDLINE), EMBASE, Cochrane Library and Web of Science were searche

SUBMITTER: Turcotte AF 

PROVIDER: S-EPMC8186797 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature