Pediatric SARS-CoV-2 seroprevalence during mitigation procedures in Southwestern Pennsylvania.

ABSTRACT:

Background

Children infected with SARS-CoV-2 are often asymptomatic or have only mild symptoms, leading to underestimation of disease prevalence in symptom-based testing strategies.

Objectives

This study sought to determine pediatric SARS-CoV-2 disease burden during local mitigation efforts by using antibody testing to compare seroprevalence estimates to cumulative PCR prevalence estimates.

Study design

In this cross-sectional study, we collected 1142 strict phase and 1196 relaxed phase remnant blood specimens from patients less than 19-years-old in southwestern Pennsylvania (SWPA). Patients were excluded if their residential zip code was outside the region of interest, if they were under 6-months-old, or they had recently received antibody-modifying treatments. Demog

SUBMITTER: Rapsinski GJ 

PROVIDER: S-EPMC8186957 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature