Identification of Ten Mitosis Genes Associated with Tamoxifen Resistance in Breast Cancer.

ABSTRACT:

Background

Endocrine therapy is the backbone therapy in estrogen receptor α (ER)-positive breast cancer, and tamoxifen resistance is a great challenge for endocrine therapy. Tamoxifen-resistant and sensitive samples from the international public repository, the Gene Expression Omnibus (GEO) database, were used to identify therapeutic biomarkers associated with tamoxifen resistance.

Materials and methods

In this study, integrated analysis was used to identify tamoxifen resistance-associated genes. Differentially expressed genes (DEGs) were identified. Gene ontology and pathway analysis were then analyzed. Weighted correlation network analysis (WGCNA) was performed to find modules correlated with tamoxifen resistance. Protein-protein interaction (PPI) network was used to find

SUBMITTER: Sun X 

PROVIDER: S-EPMC8187086 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature