Integration of population and functional genomics to understand mechanisms of artemisinin resistance in Plasmodium falciparum.

ABSTRACT: Resistance to antimalarial drugs, and in particular to the artemisinin derivatives and their partner drugs, threatens recent progress toward regional malaria elimination and eventual global malaria eradication. Population-level studies utilizing whole-genome sequencing approaches have facilitated the identification of regions of the parasite genome associated with both clinical and in vitro drug-resistance phenotypes. However, the biological relevance of genes identified in these analyses and the establishment of a causal relationship between genotype and phenotype requires functional characterization. Here we examined data from population genomic and transcriptomic studies in the context of data generated from recent functional studies, using a new population genetic approach designed to

SUBMITTER: Oberstaller J 

PROVIDER: S-EPMC8187163 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature