Exercise training improves mitochondrial respiration and is associated with an altered intramuscular phospholipid signature in women with obesity.

ABSTRACT:

Aims/hypothesis

We sought to determine putative relationships among improved mitochondrial respiration, insulin sensitivity and altered skeletal muscle lipids and metabolite signature in response to combined aerobic and resistance training in women with obesity.

Methods

This study reports a secondary analysis of a randomised controlled trial including additional measures of mitochondrial respiration, skeletal muscle lipidomics, metabolomics and protein content. Women with obesity were randomised into 12 weeks of combined aerobic and resistance exercise training (n = 20) or control (n = 15) groups. Pre- and post-intervention testing included peak oxygen consumption, whole-body insulin sensitivity (intravenous glucose tolerance test), skeletal muscle mitochondrial respiration

SUBMITTER: Mendham AE 

PROVIDER: S-EPMC8187207 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature