Identification and characterisation of tertiary lymphoid organs in human type 1 diabetes.

ABSTRACT:

Aims/hypothesis

We and others previously reported the presence of tertiary lymphoid organs (TLOs) in the pancreas of NOD mice, where they play a role in the development of type 1 diabetes. Our aims here are to investigate whether TLOs are present in the pancreas of individuals with type 1 diabetes and to characterise their distinctive features, in comparison with TLOs present in NOD mouse pancreases, in order to interpret their functional significance.

Methods

Using immunofluorescence confocal microscopy, we examined the extracellular matrix (ECM) and cellular constituents of pancreatic TLOs from individuals with ongoing islet autoimmunity in three distinct clinical settings of type 1 diabetes: at risk of diabetes; at/after diagnosis; and in the transplanted pancreas with re

SUBMITTER: Korpos E 

PROVIDER: S-EPMC8187221 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature