Structural and functional reorganization of contralateral hippocampus after temporal lobe epilepsy surgery.

ABSTRACT:

Objective

To explore the structural and functional reorganization of contralateral hippocampus in patients with unilateral mesial temporal lobe epilepsy (mTLE) who achieved seizure-freedom after anterior temporal lobectomy (ATL).

Methods

We obtained high-resolution structural MRI and resting-state functional MRI data in 28 unilateral mTLE patients and 29 healthy controls. Patients were scanned before and three and 24 months after surgery while controls were scanned only once. Hippocampal gray matter volume (GMV) and functional connectivity (FC) were assessed.

Results

No obvious GMV changes were observed in contralateral hippocampus before and after successful surgery. Before surgery, ipsilateral hippocampus showed increased FC with ipsilateral insula (INS) and temporo

SUBMITTER: Li W 

PROVIDER: S-EPMC8187253 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature