Urinary phthalate metabolite concentrations and hot flashes in women from an urban convenience sample of midlife women.

ABSTRACT:

Context

Phthalate exposure is associated with altered reproductive function, but little is known about associations of phthalate exposure with risk of hot flashes.

Objective

To investigate associations of urinary phthalate metabolite levels with four hot flash outcomes in midlife women.

Design

A cross-sectional study of the first year of a prospective cohort of midlife women, the Midlife Women's Health Study (2006-2015), a convenience sample from an urban setting.

Participants

728 multi-racial/ethnic pre- and perimenopausal women aged 45-54 years.

Outcome measures

Women completed questionnaires about hot flash experience and provided 1-4 urine samples over four consecutive weeks that were pooled for analysis. Phthalate metabolites were assessed individua

SUBMITTER: Warner GR 

PROVIDER: S-EPMC8187273 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature