Associations of Common Depression Treatment Metrics With Patient-centered Outcomes.

ABSTRACT:

Background

Various metrics predicated on Patient Health Questionnaire-9 (PHQ-9) scores denote depression "response" or "remission" over time, but few have been empirically validated. We compare the associations of depression response and remission metrics with concomitant clinical improvement in patient-centered outcomes (PCOs).

Subjects

Secondary analysis of PHQ-9 and PCO data from the treatment arm (n=906) of the Improving Mood-Promoting Access to Collaborative Treatment (IMPACT) trial.

Research design

We conducted univariate correlations between 9 depression treatment metrics and 4 PCOs. For each PCO, we specified a multivariate linear fixed-effects regression model with penalized LASSO (least absolute shrinkage and selection operator) variable selection that inclu

SUBMITTER: Carlo AD 

PROVIDER: S-EPMC8187281 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature