Differences between cigarette smoking and biomass smoke exposure: An in silico comparative assessment of particulate deposition in the lungs.

ABSTRACT: Cigarette smoking and biomass smoke are the two main environmental risk factors of chronic obstructive pulmonary disease (COPD) worldwide. However, it remains unclear why these exposures result in two different disease phenotypes. In this study, we assessed the lung deposition from biomass and cigarette smoke exposures and examined whether differences due to inherently different particle size distributions and inhalation conditions may contribute to the differences between biomass- and tobacco-related COPD phenotypes. Using high-fidelity three-dimensional computational fluid-particle dynamics in a representative upper airway geometry, coupled to one-dimensional models of the lower airways, we computed total deposited doses and examined regional deposition patterns based on exposure data fr

SUBMITTER: Nicolaou L 

PROVIDER: S-EPMC8187290 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature