Evaluation of serious bleeding signals during concomitant use of clopidogrel and hypnotic drugs.

ABSTRACT:

Background

In a previous drug-drug interaction (DDI) screening study intended to generate hypotheses, clopidogrel + either eszopiclone or zolpidem (vs. clopidogrel alone) were associated with serious bleeding.

Objectives

To confirm or refute these DDI signals and examine associations with other hypnotics in an independent population of United States Medicaid beneficiaries METHODS: We employed a bi-directional self-controlled case series design in eligible individuals concomitantly exposed to one of 12 hypnotics (precipitants, exposures of interest) plus either clopidogrel (the object drug) or pravastatin (the negative control object drug). The outcome was hospital presentation with serious bleeding. Using conditional Poisson regression, we calculated confounder-adjusted rate

SUBMITTER: Pham Nguyen TP 

PROVIDER: S-EPMC8187300 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature