Tumor metabolism and associated serum metabolites define prognostic subtypes of Asian hepatocellular carcinoma.

ABSTRACT: Treatment effectiveness in hepatocellular carcinoma (HCC) depends on early detection and precision-medicine-based patient stratification for targeted therapies. However, the lack of robust biomarkers, particularly a non-invasive diagnostic tool, precludes significant improvement of clinical outcomes for HCC patients. Serum metabolites are one of the best non-invasive means for determining patient prognosis, as they are stable end-products of biochemical processes in human body. In this study, we aimed to identify prognostic serum metabolites in HCC. To determine serum metabolites that were relevant and representative of the tissue status, we performed a two-step correlation analysis to first determine associations between metabolic genes and tissue metabolites, and second, between tissue m

SUBMITTER: Pomyen Y 

PROVIDER: S-EPMC8187378 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature