Adaptive and multifunctional hydrogel hybrid probes for long-term sensing and modulation of neural activity.

ABSTRACT: To understand the underlying mechanisms of progressive neurophysiological phenomena, neural interfaces should interact bi-directionally with brain circuits over extended periods of time. However, such interfaces remain limited by the foreign body response that stems from the chemo-mechanical mismatch between the probes and the neural tissues. To address this challenge, we developed a multifunctional sensing and actuation platform consisting of multimaterial fibers intimately integrated within a soft hydrogel matrix mimicking the brain tissue. These hybrid devices possess adaptive bending stiffness determined by the hydration states of the hydrogel matrix. This enables their direct insertion into the deep brain regions, while minimizing tissue damage associated with the brain micromotion af

SUBMITTER: Park S 

PROVIDER: S-EPMC8187649 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature