Gene expression changes and DNA damage after ex vivo exposure of peripheral blood cells to various CT photon spectra.

ABSTRACT: Dual-energy CT provides enhanced diagnostic power with similar or even reduced radiation dose as compared to single-energy CT. Its principle is based on the distinct physical properties of low and high energetic photons, which, however, may also affect the biological effectiveness and hence the extent of CT-induced cellular damage. Therefore, a comparative analysis of biological effectiveness of dual- and single-energy CT scans with focus on early gene regulation and frequency of radiation-induced DNA double strand breaks (DSBs) was performed. Blood samples from three healthy individuals were irradiated ex vivo with single-energy (80 kV and 150 kV) and dual-energy tube voltages (80 kV/Sn150kV) employing a modern dual source CT scanner resulting in Volume Computed Tomography Dose Index (CTD

SUBMITTER: Kaatsch HL 

PROVIDER: S-EPMC8187728 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature