Toxoplasma gondii Type-I ROP18 Targeting Human E3 Ligase TRIM21 for Immune Escape.

ABSTRACT: Toxoplasma gondii is an intracellular pathogen that exerts its virulence through inhibiting host's innate immune responses, which is mainly related to the type II interferon (IFN-γ) response. IFN-γ inducible tripartite motif 21 (TRIM21), an E3 ligase, plays an important role in anti-infection responses against the intracellular pathogens including bacteria, virus, and parasite. We found that T. gondii virulence factor ROP18 of the type I RH strain (TgROP18_I) interacted with human TRIM21, and promoted the latter's phosphorylation, which subsequently accelerated TRIM21 degradation through lysosomal pathway. Furthermore, TRIM21 protein level was found to be upregulated during RH and CEP strains of T. gondii infection. TRIM21 knocking down reduced the ubi

SUBMITTER: Yao L 

PROVIDER: S-EPMC8187923 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature