Targeted Drug Delivery for Sustainable Crop Protection: Transport and Stability of Polymeric Nanocarriers in Plants.

ABSTRACT: Spraying of agrochemicals (pesticides, fertilizers) causes environmental pollution on a million-ton scale. A sustainable alternative is target-specific, on-demand drug delivery by polymeric nanocarriers. Trunk injections of aqueous nanocarrier dispersions can overcome the biological size barriers of roots and leaves and allow distributing the nanocarriers through the plant. To date, the fate of polymeric nanocarriers inside a plant is widely unknown. Here, the in planta conditions in grapevine plants are simulated and the colloidal stability of a systematic series of nanocarriers composed of polystyrene (well-defined model) and biodegradable lignin and polylactic-co-glycolic acid by a combination of different techniques is studied. Despite the adsorption of carbohydrates and other biomolec

SUBMITTER: Beckers SJ 

PROVIDER: S-EPMC8188206 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature