Biocompatible metal-organic frameworks for the storage and therapeutic delivery of hydrogen sulfide.

ABSTRACT: Hydrogen sulfide (H₂S) is an endogenous gasotransmitter with potential therapeutic value for treating a range of disorders, such as ischemia-reperfusion injury resulting from a myocardial infarction or stroke. However, the medicinal delivery of H₂S is hindered by its corrosive and toxic nature. In addition, small molecule H₂S donors often generate other reactive and sulfur-containing species upon H₂S release, leading to unwanted side effects. Here, we demonstrate that H₂S release from biocompatible porous solids, namely metal-organic frameworks (MOFs), is a promising alternative strategy for H₂S delivery under physiologically relevant conditions. In particular, through gas adsorption measurements and density functional theor

SUBMITTER: Chen FE 

PROVIDER: S-EPMC8188460 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature