PINIR: a comprehensive information resource for Pin-II type protease inhibitors.

ABSTRACT:

Background

Serine protease inhibitors belonging to the Potato type-II Inhibitor family Protease Inhibitors (Pin-II type PIs) are essential plant defense molecules. They are characterized by multiple inhibitory repeat domains, conserved disulfide bond pattern, and a tripeptide reactive center loop. These features of Pin-II type PIs make them potential molecules for protein engineering and designing inhibitors for agricultural and therapeutic applications. However, the diversity in these PIs remains unexplored due to the lack of annotated protein sequences and their functional attributes in the available databases.

Results

We have developed a database, PINIR (Pin-II type PIs Information Resource), by systematic collection and manual annotation of 415 Pin-II type PI protein seq

SUBMITTER: Yadav NK 

PROVIDER: S-EPMC8188708 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature