Uncovering the Roles of Clocks and Neural Transmission in the Resilience of Drosophila Circadian Network.

ABSTRACT: Studies of circadian locomotor rhythms in Drosophila melanogaster gave evidence to the preceding theoretical predictions on circadian rhythms. The molecular oscillator in flies, as in virtually all organisms, operates using transcriptional-translational feedback loops together with intricate post-transcriptional processes. Approximately150 pacemaker neurons, each equipped with a molecular oscillator, form a circuit that functions as the central pacemaker for locomotor rhythms. Input and output pathways to and from the pacemaker circuit are dissected to the level of individual neurons. Pacemaker neurons consist of functionally diverse subclasses, including those designated as the Morning/Master (M)-oscillator essential for driving free-running locomotor rhythms in constant darkness a

SUBMITTER: Jaumouille E 

PROVIDER: S-EPMC8188733 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature