Two-dose varicella vaccine effectiveness in China: a meta-analysis and evidence quality assessment.

ABSTRACT:

Background

The objectives of this review were to evaluate the vaccine effectiveness (VE) of the two-dose varicella vaccine for healthy children in China and explore the application of the approach of Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) in observational studies on VE.

Methods

We searched for observational studies on two-dose varicella VE for children in China aged 1-12 years that were published from 1997 to 2019, and assessed the quality of each study using the Newcastle Ottawa Scale (NOS). We used meta-analysis models to obtain the pooled two-dose VE, and the studies were divided into subgroups and analysed according to whether or not it was an outbreak investigation and its NOS score. The quality of evidence of VEs were rated by approac

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC8188742 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature