Fatal encephalopathy with wild-type JC virus and ruxolitinib therapy.

ABSTRACT:

Objective

JC virus (JCV) infection is a lytic infection of oligodendrocytes in progressive multifocal leukoencephalopathy; less common forms of central nervous system manifestations associated with JCV infection include granule cell neuronopathy, encephalopathy, and meningitis. Presented is the first case of fatal JCV encephalopathy after immunosuppressive therapy that included ruxolitinib.

Methods

Postmortem analysis included next generation sequencing, Sanger sequencing, tissue immunohistochemistry, and formalin-fixed hemisphere 7T magnetic resonance imaging.

Results

JCV DNA isolated from postmortem tissue samples identified a novel 12bp insertion that altered the transcription site binding pattern in an otherwise "wild-type virus," which has long been thought to be

SUBMITTER: Reoma LB 

PROVIDER: S-EPMC8189164 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature