The immunogenicity and safety of respiratory syncytial virus vaccines in development: A systematic review.

ABSTRACT:

Background

Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory infection globally. There are vaccine candidates in development, but a systematic review on immunogenicity and safety of vaccine is lacking.

Methods

This systematic review of RSV vaccine clinical trials was undertaken using four databases. Searches were conducted using both controlled vocabulary terms such as "Respiratory Syncytial Virus, Human," "Respiratory Syncytial Virus Infections," "Respiratory Syncytial Virus Vaccines," "Immunization," "Immunization Programs" and "Vaccines" and corresponding text word terms. The included studies were limited to clinical trials published from January 2000 to 31 December 2020. RSV infection case was defined as RSV-associated medically attended acu

SUBMITTER: Shan J 

PROVIDER: S-EPMC8189192 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature