Local Therapies in Oligometastatic and Oligoprogressive Prostate Cancer.

ABSTRACT: Oligometastatic disease was originally defined by Hellman and Weichselbaum as an intermediate-state existing between locally confined and widely disseminated malignancy, whose natural history could be positively impacted with systemic and importantly local therapies such as radiation. Currently oligometastatic prostate cancer (OPCa) is defined clinically by lesion enumeration and several subgroups exist: de novo (synchronous) oligometastatic disease present at initial diagnosis, oligorecurrent (metachronous) disease arising after definitive therapy to the prostate, and oligoprogressive disease where isolated lesions progress in a background of otherwise stable disease. In this review we highlight current knowledge and the potential future of local therapies, such as radiation to the primar

SUBMITTER: Deek MP 

PROVIDER: S-EPMC8189311 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature