TMEM41B is a host factor required for the replication of diverse coronaviruses including SARS-CoV-2.

ABSTRACT: Antiviral therapeutics are a front-line defense against virally induced diseases. Because viruses frequently mutate to escape direct inhibition of viral proteins, there is interest in targeting the host proteins that the virus must co-opt to complete its replication cycle. However, a detailed understanding of the interactions between the virus and the host cell is necessary in order to facilitate development of host-directed therapeutics. As a first step, we performed a genome-wide loss of function screen using the alphacoronavirus HCoV-229E to better define the interactions between coronaviruses and host factors. We report the identification and validation of an ER-resident host protein, TMEM41B, as an essential host factor for not only HCoV-229E but also genetically distinct coronaviruse

SUBMITTER: Trimarco JD 

PROVIDER: S-EPMC8189496 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature