Risk-Based Selection of Individuals for Oral Cancer Screening.

ABSTRACT:

Purpose

We evaluated proof of principle for resource-efficient, risk-based screening through reanalysis of the Kerala Oral Cancer Screening Trial.

Methods

The cluster-randomized trial included three triennial rounds of visual inspection (seven clusters, n = 96,516) versus standard of care (six clusters, n = 95,354) and up to 9 years of follow-up. We developed a Cox regression-based risk prediction model for oral cancer incidence. Using this risk prediction model to adjust for the oral cancer risk imbalance between arms, through intention-to-treat (ITT) analyses that accounted for cluster randomization, we calculated the relative (hazard ratios [HRs]) and absolute (rate differences [RDs]) screening efficacy on oral cancer mortality and compared screening efficiency across ris

SUBMITTER: Cheung LC 

PROVIDER: S-EPMC8189638 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature